node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDY49962.1 | SDY74955.1 | SAMN05216554_0509 | SAMN05216554_1387 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ. | 0.790 |
SDY49962.1 | dnaJ | SAMN05216554_0509 | SAMN05216554_3901 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.790 |
SDY49962.1 | dnaK | SAMN05216554_0509 | SAMN05216554_1385 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.977 |
SDY49962.1 | groL | SAMN05216554_0509 | SAMN05216554_0211 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.681 |
SDY49962.1 | groS | SAMN05216554_0509 | SAMN05216554_0334 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.710 |
SDY49962.1 | grpE | SAMN05216554_0509 | SAMN05216554_1386 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.859 |
SDY49962.1 | hrcA | SAMN05216554_0509 | SAMN05216554_3900 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.633 |
SDY74955.1 | SDY49962.1 | SAMN05216554_1387 | SAMN05216554_0509 | Molecular chaperone DnaJ. | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | 0.790 |
SDY74955.1 | SDY75074.1 | SAMN05216554_1387 | SAMN05216554_1391 | Molecular chaperone DnaJ. | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | 0.790 |
SDY74955.1 | SDZ16523.1 | SAMN05216554_1387 | SAMN05216554_2726 | Molecular chaperone DnaJ. | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | 0.790 |
SDY74955.1 | dnaK | SAMN05216554_1387 | SAMN05216554_1385 | Molecular chaperone DnaJ. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
SDY74955.1 | groL | SAMN05216554_1387 | SAMN05216554_0211 | Molecular chaperone DnaJ. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.910 |
SDY74955.1 | groS | SAMN05216554_1387 | SAMN05216554_0334 | Molecular chaperone DnaJ. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.825 |
SDY74955.1 | grpE | SAMN05216554_1387 | SAMN05216554_1386 | Molecular chaperone DnaJ. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.998 |
SDY74955.1 | hrcA | SAMN05216554_1387 | SAMN05216554_3900 | Molecular chaperone DnaJ. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.839 |
SDY74955.1 | rplP | SAMN05216554_1387 | SAMN05216554_0378 | Molecular chaperone DnaJ. | LSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.807 |
SDY75074.1 | SDY74955.1 | SAMN05216554_1391 | SAMN05216554_1387 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ. | 0.790 |
SDY75074.1 | dnaJ | SAMN05216554_1391 | SAMN05216554_3901 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.790 |
SDY75074.1 | dnaK | SAMN05216554_1391 | SAMN05216554_1385 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.977 |
SDY75074.1 | groL | SAMN05216554_1391 | SAMN05216554_0211 | ATP-dependent Clp protease ATP-binding subunit ClpB; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.681 |