node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acnM | prpB | H16_A1907 | H16_A1905 | Methyl-cis-aconitic acid hydratase/Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Methylisocitric acid lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.913 |
acnM | prpC1 | H16_A1907 | H16_A1906 | Methyl-cis-aconitic acid hydratase/Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 2-Methylcitrate synthase 1; Belongs to the citrate synthase family. | 0.996 |
acnM | prpD1 | H16_A1907 | H16_A1909 | Methyl-cis-aconitic acid hydratase/Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 2-Methylcitrate dehydratase. | 0.962 |
acoE | h16_A1197 | H16_A2525 | H16_A1197 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | Acyl-CoA synthetase. | 0.736 |
acoE | h16_A1616 | H16_A2525 | H16_A1616 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | Acetyl-coenzyme A synthetase. | 0.680 |
acoE | h16_B0834 | H16_A2525 | H16_B0834 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | Acetate-CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.651 |
acoE | h16_B1102 | H16_A2525 | H16_B1102 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | Acetyl-CoA synthetase. | 0.731 |
acoE | mmsA1 | H16_A2525 | H16_A0273 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | Methylmalonate-semialdehyde dehydrogenase. | 0.937 |
acoE | prpB | H16_A2525 | H16_A1905 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | Methylisocitric acid lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.886 |
acoE | prpC1 | H16_A2525 | H16_A1906 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | 2-Methylcitrate synthase 1; Belongs to the citrate synthase family. | 0.948 |
acoE | prpE | H16_A2525 | H16_A2462 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | Propionate-CoA ligase. | 0.917 |
h16_A1197 | acoE | H16_A1197 | H16_A2525 | Acyl-CoA synthetase. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Although acetate is the preferred substrate of AcsA, propionate is also used, but at a diminished rate compared with that of acetate. Fatty acid [...] | 0.736 |
h16_A1197 | h16_A1616 | H16_A1197 | H16_A1616 | Acyl-CoA synthetase. | Acetyl-coenzyme A synthetase. | 0.738 |
h16_A1197 | h16_B0834 | H16_A1197 | H16_B0834 | Acyl-CoA synthetase. | Acetate-CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.737 |
h16_A1197 | h16_B1102 | H16_A1197 | H16_B1102 | Acyl-CoA synthetase. | Acetyl-CoA synthetase. | 0.711 |
h16_A1197 | mmsA1 | H16_A1197 | H16_A0273 | Acyl-CoA synthetase. | Methylmalonate-semialdehyde dehydrogenase. | 0.937 |
h16_A1197 | prpB | H16_A1197 | H16_A1905 | Acyl-CoA synthetase. | Methylisocitric acid lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.886 |
h16_A1197 | prpC1 | H16_A1197 | H16_A1906 | Acyl-CoA synthetase. | 2-Methylcitrate synthase 1; Belongs to the citrate synthase family. | 0.948 |
h16_A1197 | prpD1 | H16_A1197 | H16_A1909 | Acyl-CoA synthetase. | 2-Methylcitrate dehydratase. | 0.589 |
h16_A1197 | prpE | H16_A1197 | H16_A2462 | Acyl-CoA synthetase. | Propionate-CoA ligase. | 0.941 |