STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadAQuinolinate synthetase A protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (384 aa)    
Predicted Functional Partners:
nadB
L-Aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
 0.999
nadC
Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family.
 
 0.999
h16_B0560
Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Belongs to the NadC/ModD family.
 
 0.997
h16_B0736
Predicted dinucleotide-utilizing enzyme; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
    
 0.926
cysE
Serine acetyltransferase; CysE.
  
    0.750
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
  
 0.715
menC
L-Alanine-DL-glutamate epimerase.
      
 0.713
h16_B0494
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
  
  
 0.686
iscS
Cysteine desulfurase (IscS); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
  
  
 0.668
h16_A0545
Uncharacterized protein conserved in bacteria,putative regulatory protein; Modulates RecA activity; Belongs to the RecX family.
     
 0.662
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.