STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdcBThreonine deaminase. (321 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase III small subunit.
  
 
 0.836
thrC
Threonine synthase.
  
 
 0.781
h16_B0280
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.688
ilvB
Acetolactate synthase III (valine sensitive).
  
 0.669
h16_A2231
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
  
 0.669
h16_B0313
Acetolactate synthase large subunit (TPP dependent); Belongs to the TPP enzyme family.
  
 0.669
h16_B0589
Thiamine pyrophosphate-requiring enzyme.
  
 0.669
h16_A2987
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 0.662
h16_A3087
Anthranilate/para-aminobenzoate synthase component I.
  
  
 0.643
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.635
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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