STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phaZ5Intracellular poly(3-hydroxybutyrate) depolymerase. (407 aa)    
Predicted Functional Partners:
phaC1
Poly(3-hydroxybutyrate) polymerase; Polymerizes (R)-3-hydroxybutyryl-CoA to create polyhydroxybutyrate (PHB) which consists of thousands of hydroxybutyrate molecules linked end to end. PHB serves as an intracellular energy reserve material when cells grow under conditions of nutrient limitation; Belongs to the PHA/PHB synthase family. Type I PhaC subfamily.
 
  
 0.973
phaC2
Poly(3-hydroxybutyrate) polymerase.
 
  
 0.972
phaZ7
Poly(3-hydroxybutyrate) depolymerase.
    
 0.962
phaZ3
Intracellular poly(3-hydroxybutyrate) depolymerase.
  
  
0.918
phaZ1
Intracellular poly(3-hydroxybutyrate) depolymerase.
  
  
0.909
phaZ6
Poly(3-hydroxybutyrate) depolymerase.
    
 0.909
phaZ2
Intracellular poly(3-hydroxybutyrate) depolymerase.
  
  
 
0.908
phaY1
D-(-)-3-hydroxybutyrate oligomer hydrolase; Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB- oligomers) into 3HB-monomers. Seems to have also poly(3- hydroxybutyrate) depolymerase activity since it is able to release 3HB- monomers from artificial amorphous PHB.
     
  0.900
phaR
Transcriptional regulator of phasin expression.
 
   
 0.624
h16_A1814
D-beta-hydroxybutyrate dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
   
 0.521
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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