node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHK40292.1 | SHK40604.1 | SAMN05444391_0899 | SAMN05444391_0910 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | 0.972 |
SHK40292.1 | SHK48654.1 | SAMN05444391_0899 | SAMN05444391_1182 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.954 |
SHK40292.1 | adk | SAMN05444391_0899 | SAMN05444391_0824 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.934 |
SHK40292.1 | ftsH | SAMN05444391_0899 | SAMN05444391_0845 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.890 |
SHK40292.1 | gmk | SAMN05444391_0899 | SAMN05444391_1291 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.965 |
SHK40292.1 | guaA | SAMN05444391_0899 | SAMN05444391_0308 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.981 |
SHK40292.1 | guaB | SAMN05444391_0899 | SAMN05444391_0257 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.966 |
SHK40292.1 | purA | SAMN05444391_0899 | SAMN05444391_1350 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.972 |
SHK40292.1 | purH | SAMN05444391_0899 | SAMN05444391_1152 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.969 |
SHK40292.1 | tilS | SAMN05444391_0899 | SAMN05444391_1370 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.962 |
SHK40604.1 | SHK40292.1 | SAMN05444391_0910 | SAMN05444391_0899 | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.972 |
SHK40604.1 | SHK48654.1 | SAMN05444391_0910 | SAMN05444391_1182 | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.967 |
SHK40604.1 | ftsH | SAMN05444391_0910 | SAMN05444391_0845 | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.565 |
SHK40604.1 | gmk | SAMN05444391_0910 | SAMN05444391_1291 | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.472 |
SHK40604.1 | guaA | SAMN05444391_0910 | SAMN05444391_0308 | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.982 |
SHK40604.1 | guaB | SAMN05444391_0910 | SAMN05444391_0257 | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.967 |
SHK40604.1 | purA | SAMN05444391_0910 | SAMN05444391_1350 | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.970 |
SHK40604.1 | purH | SAMN05444391_0910 | SAMN05444391_1152 | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.981 |
SHK48654.1 | SHK40292.1 | SAMN05444391_1182 | SAMN05444391_0899 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.954 |
SHK48654.1 | SHK40604.1 | SAMN05444391_1182 | SAMN05444391_0910 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | 0.967 |