node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fnod_0772 | Fnod_1150 | Fnod_0772 | Fnod_1150 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.909 |
Fnod_0772 | fhs | Fnod_0772 | Fnod_1079 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.962 |
Fnod_0772 | folD | Fnod_0772 | Fnod_1338 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.639 |
Fnod_0772 | gcvH | Fnod_0772 | Fnod_1020 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.559 |
Fnod_0772 | gcvPB | Fnod_0772 | Fnod_0974 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.541 |
Fnod_0772 | gcvT | Fnod_0772 | Fnod_0976 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.964 |
Fnod_0772 | glyA | Fnod_0772 | Fnod_0085 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.947 |
Fnod_0772 | purN | Fnod_0772 | Fnod_1674 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
Fnod_1150 | Fnod_0772 | Fnod_1150 | Fnod_0772 | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | 0.909 |
Fnod_1150 | fhs | Fnod_1150 | Fnod_1079 | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.972 |
Fnod_1150 | folD | Fnod_1150 | Fnod_1338 | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.967 |
Fnod_1150 | gcvPB | Fnod_1150 | Fnod_0974 | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.497 |
Fnod_1150 | gcvT | Fnod_1150 | Fnod_0976 | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
Fnod_1150 | glyA | Fnod_1150 | Fnod_0085 | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
Fnod_1150 | purN | Fnod_1150 | Fnod_1674 | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
Fnod_1474 | glyA | Fnod_1474 | Fnod_0085 | TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain; KEGG: tte:TTE1009 L-serine deaminase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
fhs | Fnod_0772 | Fnod_1079 | Fnod_0772 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. | 0.962 |
fhs | Fnod_1150 | Fnod_1079 | Fnod_1150 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | IMP cyclohydrolase; PFAM: MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region; KEGG: tte:TTE0592 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.972 |
fhs | folD | Fnod_1079 | Fnod_1338 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | gcvH | Fnod_1079 | Fnod_1020 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.419 |