STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (718 aa)    
Predicted Functional Partners:
EDY81421.1
NOL1/NOP2/sun family, putative; [J] COG0144 tRNA and rRNA cytosine-C5-methylases; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.822
EDY82454.1
[L] COG1793 ATP-dependent DNA ligase.
    
 0.781
EDY81254.1
UvrD/REP helicase subfamily; [L] COG0210 Superfamily I DNA and RNA helicases.
 
  
 0.753
EDY84331.1
[C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit.
   
   0.746
leuS
[J] COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 
 0.710
murB
UDP-N-acetylenolpyruvoylglucosamine reductase, putative; Cell wall formation.
 
 
 0.705
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
  
   
 0.651
EDY82458.1
[L] COG0587 DNA polymerase III, alpha subunit; Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
 
  
 0.580
EDY84317.1
UvrC Helix-hairpin-helix N-terminal domain family; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
  
 0.574
EDY80914.1
Acetyltransferase, GNAT family; [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases.
       0.552
Your Current Organism:
Verrucomicrobiae bacterium DG1235
NCBI taxonomy Id: 382464
Other names: V. bacterium DG1235, Verrucomicrobiae bacterium str. DG1235, Verrucomicrobiae bacterium strain DG1235, Verrucomicrobiales bacterium DG1235
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