EDY83958.1 protein (Verrucomicrobiae bacterium DG1235)

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Predicted Interactions

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Score

EDY83958.1

Transporter, SSS family, putative; [ER] COG0591 Na+/proline symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (578 aa)

Predicted Functional Partners:

EDY80889.1

0.858

EDY83271.1

0.721

EDY84344.1

0.716

EDY81281.1

0.686

EDY82890.1

0.682

EDY82901.1

0.682

EDY83608.1

0.682

EDY85142.1

0.682

EDY82182.1

0.671

EDY82616.1

0.659

Your Current Organism:

Verrucomicrobiae bacterium DG1235

NCBI taxonomy Id: 382464
Other names: V. bacterium DG1235, Verrucomicrobiae bacterium str. DG1235, Verrucomicrobiae bacterium strain DG1235, Verrucomicrobiales bacterium DG1235

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDY80889.1	EDY81281.1	VDG1235_506	VDG1235_899	Aldehyde dehydrogenase (NAD) family protein; [E] COG0506 Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	0.437
EDY80889.1	EDY82182.1	VDG1235_506	VDG1235_1802	Aldehyde dehydrogenase (NAD) family protein; [E] COG0506 Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.464
EDY80889.1	EDY83958.1	VDG1235_506	VDG1235_3585	Aldehyde dehydrogenase (NAD) family protein; [E] COG0506 Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Transporter, SSS family, putative; [ER] COG0591 Na+/proline symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.858
EDY80889.1	EDY84344.1	VDG1235_506	VDG1235_3975	Aldehyde dehydrogenase (NAD) family protein; [E] COG0506 Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.466
EDY81281.1	EDY80889.1	VDG1235_899	VDG1235_506	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	Aldehyde dehydrogenase (NAD) family protein; [E] COG0506 Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.437
EDY81281.1	EDY82182.1	VDG1235_899	VDG1235_1802	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.999
EDY81281.1	EDY82890.1	VDG1235_899	VDG1235_2513	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.999
EDY81281.1	EDY82901.1	VDG1235_899	VDG1235_2524	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	[T] COG2198 FOG: HPt domain.	0.997
EDY81281.1	EDY83608.1	VDG1235_899	VDG1235_3235	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDY81281.1	EDY83958.1	VDG1235_899	VDG1235_3585	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	Transporter, SSS family, putative; [ER] COG0591 Na+/proline symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.686
EDY81281.1	EDY84344.1	VDG1235_899	VDG1235_3975	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.999
EDY81281.1	EDY85142.1	VDG1235_899	VDG1235_4777	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.999
EDY82182.1	EDY80889.1	VDG1235_1802	VDG1235_506	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	Aldehyde dehydrogenase (NAD) family protein; [E] COG0506 Proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.464
EDY82182.1	EDY81281.1	VDG1235_1802	VDG1235_899	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG2202 FOG: PAS/PAC domain.	0.999
EDY82182.1	EDY82890.1	VDG1235_1802	VDG1235_2513	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.997
EDY82182.1	EDY82901.1	VDG1235_1802	VDG1235_2524	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	[T] COG2198 FOG: HPt domain.	0.996
EDY82182.1	EDY83608.1	VDG1235_1802	VDG1235_3235	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.997
EDY82182.1	EDY83958.1	VDG1235_1802	VDG1235_3585	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	Transporter, SSS family, putative; [ER] COG0591 Na+/proline symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.671
EDY82182.1	EDY84344.1	VDG1235_1802	VDG1235_3975	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.997
EDY82182.1	EDY85142.1	VDG1235_1802	VDG1235_4777	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.997

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009097

Isoleucine biosynthetic process

7 of 14

2.26

5.34

2.79e-12

GO:0009099

Valine biosynthetic process

5 of 10

2.26

3.86

1.31e-08

GO:1901607

Alpha-amino acid biosynthetic process

10 of 104

1.55

3.16

1.07e-12

GO:0046394

Carboxylic acid biosynthetic process

11 of 166

1.39

2.55

1.07e-12

GO:0043650

Dicarboxylic acid biosynthetic process

3 of 19

1.76

1.4

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000287

Magnesium ion binding

5 of 65

1.45

1.34

0.00046

GO:0019842

Vitamin binding

4 of 46

1.5

1.14

0.0026

GO:0015930

Glutamate synthase activity

2 of 2

2.56

1.12

0.0090

GO:0004455

Ketol-acid reductoisomerase activity

2 of 2

2.56

1.12

0.0090

GO:0050661

NADP binding

3 of 22

1.7

1.01

0.0090

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005948

Acetolactate synthase complex

2 of 2

2.56

1.39

0.0028

GO:0005829

Cytosol

7 of 324

0.9

0.76

0.00080

GO:0005737

Cytoplasm

9 of 1245

0.42

0.29

0.0348

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:993

Branched-chain amino acid metabolic process

6 of 23

1.98

3.5

1.00e-08

CL:924

Branched-chain amino acid metabolic process, and Aspartate family amino acid biosynthetic process

8 of 58

1.7

3.32

2.20e-10

CL:923

Alpha-amino acid biosynthetic process, and Dicarboxylic acid metabolic process

9 of 84

1.59

3.09

5.47e-11

CL:996

Branched-chain amino acid metabolic process

4 of 17

1.94

2.12

3.68e-05

CL:810

Glutamate biosynthetic process, and Ammonia ligase activity

2 of 5

2.17

0.87

0.0239

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

7 of 22

2.07

4.63

1.56e-11

map00770

Pantothenate and CoA biosynthesis

6 of 21

2.02

3.94

8.68e-10

map01210

2-Oxocarboxylic acid metabolism

6 of 51

1.63

2.58

7.73e-08

map01230

Biosynthesis of amino acids

10 of 159

1.36

2.38

1.56e-11

map00660

C5-Branched dibasic acid metabolism

2 of 10

1.87

1.09

0.0074

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

2 of 4

2.26

1.07

0.0102

GOCC:0005737

Cytoplasm

10 of 946

0.59

0.47

0.0014

GOCC:0005622

Intracellular

11 of 1345

0.48

0.39

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

4 of 14

2.02

2.3

1.87e-05

KW-0412

Isoleucine biosynthesis

2 of 3

2.39

1.26

0.0047

KW-0663

Pyridoxal phosphate

3 of 40

1.44

0.92

0.0091

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04898

Glutamate synthase central domain

2 of 2

2.56

0.85

0.0286

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

2 of 2

2.56

0.85

0.0286

PF01645

Conserved region in glutamate synthase

2 of 2

2.56

0.85

0.0286

PF01493

GXGXG motif

2 of 2

2.56

0.85

0.0286

PF01450

Acetohydroxy acid isomeroreductase, catalytic domain

2 of 2

2.56

0.85

0.0286

(more ...)

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