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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (472 aa)    
Predicted Functional Partners:
SPRI_0180
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.989
SPRI_5899
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.956
SPRI_4467
Cystathionine beta-synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.929
SPRI_2931
Cystathionine gamma-synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.923
SPRI_4676
DNA methylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
    
 0.906
SPRI_4677
5-methylcytosine methyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.906
SPRI_1856
Homocysteine methyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
  0.900
SPRI_3595
Bifunctional beta-cystathionase/maltose regulon regulatory protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
  0.900
ahcY-2
S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
  
 
0.900
samS
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.891
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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