Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (311 aa)    
Predicted Functional Partners:
SPRI_3353
uroporphyrin-III C-methyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 0.998
SPRI_3351
Delta-aminolevulinic acid dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.
 
 0.997
SPRI_6011
Uroporphyrinogen III methylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family.
  
 0.990
SPRI_4584
uroporphyrinogen-III synthetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.980
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.971
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.950
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.924
hemC-2
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
  
 
0.917
SPRI_2019
Glutamate-1-semialdehyde 2,1-aminomutase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.817
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.635
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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