Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (283 aa)    
Predicted Functional Partners:
SPRI_5209
Bifunctional RNase H/acid phosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
  0.904
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.803
SPRI_3811
Single-stranded DNA-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.642
SPRI_4837
Single-stranded DNA-binding domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.642
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 
 
 0.550
SPRI_5208
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.539
SPRI_5052
Hydroxylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.530
SPRI_6671
Aldo/keto reductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.530
SPRI_0615
Putative membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.517
SPRI_6623
3-demethylubiquinone-9 3-methyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.496
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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