close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_0810Phosphoesterase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (575 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.956
SPRI_5932
DNA polymerase I; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.891
lig
ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
 
 0.878
SPRI_1068
ATP-dependent DNA ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 0.877
SPRI_0779
3'-phosphoesterase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.856
SPRI_2571
DNA ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.856
SPRI_1888
Haloacid dehalogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
    
 0.832
SPRI_1889
Transferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.832
SPRI_1382
Exodeoxyribonuclease III; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.811
SPRI_4371
Exodeoxyribonuclease; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.811
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.