Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRI_1231Acetolactate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (561 aa)    
Predicted Functional Partners:
frc
Formyl-coenzyme A transferase; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate; Belongs to the CoA-transferase III family. Frc subfamily.
 
 
 0.977
SPRI_1233
CoA-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
 
 0.959
SPRI_2357
Acetolactate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
 0.948
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.927
SPRI_1234
MFS transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
   
 0.922
SPRI_1228
Dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
 0.821
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.768
SPRI_2926
Threonine dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.726
ilvD
Dihydroxy-acid dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
 
 
 0.710
SPRI_0867
Dihydroxy-acid dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
 
 
 0.689
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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