Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_12582-dehydropantoate 2-reductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (329 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.936
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
    
 0.933
SPRI_1261
NADH dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.917
SPRI_1260
NADH dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.875
SPRI_3226
DNA repair protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
    0.849
fdhD
Formate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.
       0.840
SPRI_1259
Formate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
 
     0.832
SPRI_2874
Alkylated DNA repair protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
    0.707
SPRI_1233
CoA-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.703
SPRI_1231
Acetolactate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.
 
   
 0.677
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.