Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_1346NAD-dependent deacetylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (248 aa)    
Predicted Functional Partners:
SPRI_5759
Transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 
 0.993
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.948
nadD
Nicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.933
SPRI_4632
Amidase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.919
nadK
Inorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.919
SPRI_2960
Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.914
SPRI_2689
NUDIX hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.913
SPRI_2687
ATP-dependent DNA helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.875
SPRI_3366
Acetoin utilization protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
    
 0.862
SPRI_4509
Transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.819
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.