STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_1356Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (587 aa)    
Predicted Functional Partners:
hutU
Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
 
 0.997
hutI
Imidazolonepropionase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.967
hutH
Histidine ammonia-lyase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 
0.923
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
    
 0.921
egtD
Methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family.
     
  0.900
SPRI_3638
Hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.747
SPRI_5652
Amidohydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.747
SPRI_4778
Agmatinase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the arginase family.
  
  
 0.678
SPRI_4480
N-formimino-L-glutamate deiminase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.654
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.599
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
Server load: medium (60%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.