Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_1392Dioxygenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (450 aa)    
Predicted Functional Partners:
SPRI_1391
Shy6-polyketide cyclase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.628
nnrD
YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]
   
  
 0.601
purD
Phosphoribosylamine--glycine ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the GARS family.
      
 0.531
egtD
Methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family.
      
 0.517
SPRI_1393
MFS transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.504
SPRI_4537
Lipoprotein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
      
 0.482
SPRI_5971
LysR family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family.
       0.476
SPRI_6280
Protein of unknown function DUF1503; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
     0.468
SPRI_1844
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
    
 0.428
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.