STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_1478Saccharopine dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (359 aa)    
Predicted Functional Partners:
SPRI_1477
AdpA family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
    0.701
SPRI_6422
Transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
     0.609
SPRI_6826
TetR family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
     0.498
SPRI_6679
3-hexulose-6-phosphate isomerase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.472
SPRI_1774
Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
     0.455
SPRI_4474
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
     0.440
SPRI_5710
enoyl-ACP reductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
      
 0.439
SPRI_1633
Resolvase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
      
 0.434
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.434
SPRI_1479
Transmembrane transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.417
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.