STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_1532ATP-dependent helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (157 aa)    
Predicted Functional Partners:
SPRI_2144
DNA glycosylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the FPG family.
  
  
 0.846
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
   
    0.685
SPRI_4886
DNA glycosylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the FPG family.
  
  
 0.636
SPRI_0123
Methyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.490
SPRI_7230
Methyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.490
SPRI_0776
DNA lyase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the FPG family.
  
  
 0.471
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.471
SPRI_6599
formamidopyrimidine-DNA glycosylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the FPG family.
  
  
 0.471
SPRI_2687
ATP-dependent DNA helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.465
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
   
    0.452
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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