Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (375 aa)    
Predicted Functional Partners:
SPRI_1781
Chlorite dismutase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 0.997
SPRI_1782
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
 
 0.997
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.973
SPRI_5671
Magnesium chelatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.947
SPRI_5243
Heme oxygenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
    
 0.923
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
 0.922
SPRI_5386
Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family.
     
 0.921
SPRI_6808
Copper oxidase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 
 0.918
SPRI_2046
Inositol-phosphate phosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily.
  
    0.869
SPRI_1609
Iron ABC transporter substrate-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.812
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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