close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_2247TetR family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (179 aa)    
Predicted Functional Partners:
SPRI_2248
DNA-directed RNA polymerase sigma-70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
     0.820
SPRI_2249
DNA polymerase III subunit beta; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.683
SPRI_0424
TetR family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
     0.682
SPRI_2250
Mg chelatase-like protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.681
SPRI_2251
UPF0102 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0102 family.
       0.681
SPRI_2252
Protein often found in actinomycetes clustered with signal peptidase and/or RNaseHII; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.646
SPRI_2253
DNA mismatch repair protein MutT; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family.
       0.639
SPRI_2254
Signal peptidase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.
       0.639
SPRI_2246
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.628
SPRI_3736
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
     0.627
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
Server load: high (82%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.