Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRI_2341Branched-chain amino acid aminotransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (368 aa)    
Predicted Functional Partners:
SPRI_2335
Transferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.987
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 0.987
ilvD
Dihydroxy-acid dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
  
 0.979
SPRI_2926
Threonine dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.945
SPRI_0301
Branched-chain alpha-keto acid decarboxylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.937
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.931
SPRI_3940
Valine dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.925
pglC
2-oxoisovalerate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.924
SPRI_3703
2-oxoisovalerate dehydrogenase subunit beta; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.924
SPRI_3720
2-oxoisovalerate dehydrogenase subunit beta; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.924
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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