Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRI_2360Dihydrofolate reductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
 
 
 0.791
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.731
SPRI_2357
Acetolactate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.724
SPRI_2359
Integral membrane phosphodiesterase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
 0.703
SPRI_2358
Acetolactate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.681
SPRI_2363
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.669
SPRI_2361
Oxidoreductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.656
SPRI_2355
3-phosphoglycerate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
    
0.642
SPRI_1192
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.477
SPRI_2362
Glucose sorbosone dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.475
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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