nucS protein (Streptomyces pristinaespiralis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

nucS

UPF0286 protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (220 aa)

Predicted Functional Partners:

whiB-2

0.752

SPRI_6179

0.749

SPRI_2505

0.745

SPRI_2503

0.740

SPRI_3783

0.737

whiB

0.736

SPRI_4837

0.732

whiB-7

0.730

SPRI_2515

0.718

SPRI_3780

0.716

Your Current Organism:

Streptomyces pristinaespiralis

NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPRI_2503	SPRI_2515	SPRI_2503	SPRI_2515	ATP/GTP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Secreted protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.718
SPRI_2503	nucS	SPRI_2503	SPRI_2506	ATP/GTP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	UPF0286 protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.	0.740
SPRI_2505	nucS	SPRI_2505	SPRI_2506	Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	UPF0286 protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.	0.745
SPRI_2515	SPRI_2503	SPRI_2515	SPRI_2503	Secreted protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	ATP/GTP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.718
SPRI_2515	nucS	SPRI_2515	SPRI_2506	Secreted protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	UPF0286 protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.	0.718
SPRI_3780	SPRI_3783	SPRI_3780	SPRI_3783	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.878
SPRI_3780	SPRI_4837	SPRI_3780	SPRI_4837	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	Single-stranded DNA-binding domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.564
SPRI_3780	SPRI_6179	SPRI_3780	SPRI_6179	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	Transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.705
SPRI_3780	nucS	SPRI_3780	SPRI_2506	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	UPF0286 protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.	0.716
SPRI_3780	whiB	SPRI_3780	SPRI_1052	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	Transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	0.619
SPRI_3780	whiB-2	SPRI_3780	SPRI_2636	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	0.671
SPRI_3780	whiB-7	SPRI_3780	SPRI_4523	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	0.645
SPRI_3783	SPRI_3780	SPRI_3783	SPRI_3780	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	0.878
SPRI_3783	SPRI_4837	SPRI_3783	SPRI_4837	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Single-stranded DNA-binding domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.653
SPRI_3783	SPRI_6179	SPRI_3783	SPRI_6179	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.408
SPRI_3783	nucS	SPRI_3783	SPRI_2506	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	UPF0286 protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.	0.737
SPRI_4837	SPRI_3780	SPRI_4837	SPRI_3780	Single-stranded DNA-binding domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Putative UPF0232 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0232 family.	0.564
SPRI_4837	SPRI_3783	SPRI_4837	SPRI_3783	Single-stranded DNA-binding domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.653
SPRI_4837	SPRI_6179	SPRI_4837	SPRI_6179	Single-stranded DNA-binding domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.735
SPRI_4837	nucS	SPRI_4837	SPRI_2506	Single-stranded DNA-binding domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	UPF0286 protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.	0.732