STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_2570ATP-dependent DNA ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (295 aa)    
Predicted Functional Partners:
SPRI_0779
3'-phosphoesterase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.993
ku
DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.987
SPRI_1068
ATP-dependent DNA ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.984
SPRI_2571
DNA ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.977
SPRI_6912
ATP-dependent DNA ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
0.924
lig
ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.891
ku-2
DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.875
SPRI_2572
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.615
SPRI_2573
PBS lyase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
 0.502
ligA
NAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
      
 0.465
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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