STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_2592Pentapeptide repeats domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (267 aa)    
Predicted Functional Partners:
SPRI_2079
DNA topoisomerase IV subunit B; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 
 0.679
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.679
SPRI_6502
DNA gyrase subunit B; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 
 0.679
lon
Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
  
    0.644
SPRI_0486
GlcNAc-PI de-N-acetylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.555
SPRI_0487
Alpha/beta hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.555
SPRI_6487
LacI family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.555
SPRI_6489
Sugar ABC transporter substrate-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.532
SPRI_6488
L-rhamnose mutarotase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.531
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.