STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)    
Predicted Functional Partners:
SPRI_3030
Fumarate reductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 0.995
SPRI_2823
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.988
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.983
SPRI_2772
Succinate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 0.982
SPRI_0754
Succinate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 0.976
SPRI_4812
Type II citrate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
  
 0.965
SPRI_3031
Succinate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.964
SPRI_3028
Succinate dehydrogenase cytochrome b-556 subunit; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.961
sucC-2
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 
 0.959
SPRI_0753
Succinate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.956
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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