Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRI_3067Isocitrate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (409 aa)    
Predicted Functional Partners:
SPRI_2599
Alpha-ketoglutarate decarboxylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.996
SPRI_1818
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.995
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.985
SPRI_2823
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.978
SPRI_3244
2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.954
SPRI_5483
Glutamate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.943
SPRI_4216
Citrate synthase 2; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
  
 0.929
SPRI_4812
Type II citrate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
  
 0.929
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.929
SPRI_6612
Isocitrate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family.
    
 0.929
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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