nnrD protein (Streptomyces pristinaespiralis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

nnrD

YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...] (495 aa)

Predicted Functional Partners:

SPRI_3144

0.921

SPRI_5220

0.889

SPRI_5749

0.847

glmS

0.843

acpS

0.840

SPRI_0831

0.821

SPRI_2676

0.821

SPRI_3534

0.821

SPRI_4127

0.821

SPRI_1260

0.810

Your Current Organism:

Streptomyces pristinaespiralis

NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPRI_0831	SPRI_5220	SPRI_0831	SPRI_5220	Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_0831	nnrD	SPRI_0831	SPRI_3147	Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]	0.821
SPRI_1260	nnrD	SPRI_1260	SPRI_3147	NADH dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]	0.810
SPRI_2676	SPRI_5220	SPRI_2676	SPRI_5220	NUDIX hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_2676	nnrD	SPRI_2676	SPRI_3147	NUDIX hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]	0.821
SPRI_3144	acpS	SPRI_3144	SPRI_3149	ATP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	ACP synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.	0.726
SPRI_3144	glmS	SPRI_3144	SPRI_3150	ATP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Glutamine amidotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.514
SPRI_3144	nnrD	SPRI_3144	SPRI_3147	ATP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]	0.921
SPRI_3534	SPRI_5220	SPRI_3534	SPRI_5220	NUDIX hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_3534	nnrD	SPRI_3534	SPRI_3147	NUDIX hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]	0.821
SPRI_4127	SPRI_5220	SPRI_4127	SPRI_5220	DUF4031 domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_4127	nnrD	SPRI_4127	SPRI_3147	DUF4031 domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]	0.821
SPRI_5220	SPRI_0831	SPRI_5220	SPRI_0831	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_5220	SPRI_2676	SPRI_5220	SPRI_2676	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	NUDIX hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_5220	SPRI_3534	SPRI_5220	SPRI_3534	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	NUDIX hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_5220	SPRI_4127	SPRI_5220	SPRI_4127	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	DUF4031 domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_5220	SPRI_5749	SPRI_5220	SPRI_5749	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	ADP-ribose pyrophosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_5220	nnrD	SPRI_5220	SPRI_3147	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]	0.889
SPRI_5749	SPRI_5220	SPRI_5749	SPRI_5220	ADP-ribose pyrophosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	Helicase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	0.601
SPRI_5749	nnrD	SPRI_5749	SPRI_3147	ADP-ribose pyrophosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.	YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...]	0.847

page 1 of 2

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About