STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa)    
Predicted Functional Partners:
SPRI_2349
Proline dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.970
proB
Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 
 0.944
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.925
SPRI_1200
Proline racemase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the proline racemase family.
    
 0.921
SPRI_2348
1-pyrroline-5-carboxylate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
 0.912
SPRI_0760
Proline iminopeptidase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the peptidase S33 family.
    
  0.903
gpsA
Glycerol-3-phosphate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
   
 
 0.875
SPRI_1572
Tartronate semialdehyde reductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
      
 0.859
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
 0.817
SPRI_3371
Antibiotic ABC transporter permease; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.772
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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