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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_3386Adenine glycosylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (304 aa)    
Predicted Functional Partners:
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.872
SPRI_4371
Exodeoxyribonuclease; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.870
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
     
 0.854
SPRI_1382
Exodeoxyribonuclease III; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
    
 0.841
SPRI_3385
Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.738
SPRI_3387
RNA polymerase sigma factor; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily.
       0.738
SPRI_3388
Lipoprotein cseA; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.738
SPRI_3389
Transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.717
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
   
 0.700
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
  
0.699
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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