Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRI_3419Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (285 aa)    
Predicted Functional Partners:
SPRI_3421
Diguanylate cyclase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 0.999
SPRI_3422
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 0.999
SPRI_4905
Dihydrofolate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 0.997
folE
GTP cyclohydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.975
folE-2
GTP cyclohydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.947
SPRI_2736
Inactive dihydropteroate synthase 2; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
  
0.928
SPRI_3420
3-dehydroquinate dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.875
papA
P-aminobenzoate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.781
SPRI_7047
P-aminobenzoate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.781
SPRI_3418
Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
 0.766
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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