Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRI_3524Inhibition of morphological differentiation protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (282 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.734
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.680
priA
Phosphoribosyl isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family.
  
  
 0.672
hisB
Imidazoleglycerol-phosphate dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.659
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.658
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
 
  
 0.622
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.612
SPRI_2155
Two-component system sensor kinase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
 0.607
hisE
phosphoribosyl-ATP pyrophosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.573
SPRI_3525
Oxidoreductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
      
 0.564
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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