STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhaApH-dependent sodium/proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (465 aa)    
Predicted Functional Partners:
SPRI_3531
Transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.752
acsA
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
       0.739
SPRI_3528
Integral membrane transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.678
SPRI_3532
Alpha/beta hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.656
mscL
Mechanosensitive ion channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
     
 0.523
SPRI_4123
Triacylglycerol lipase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
    0.464
SPRI_0915
Putative caspase domain protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
    0.448
SPRI_1268
Metallophosphoesterase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
    0.448
SPRI_2233
Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
    0.448
SPRI_2472
Hydrogenase maturation protein HypF; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
    0.448
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.