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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (280 aa)    
Predicted Functional Partners:
SPRI_4371
Exodeoxyribonuclease; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 0.959
SPRI_3534
NUDIX hydrolase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
 0.814
SPRI_3536
Crp/Fnr family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
   
 0.766
SPRI_3533
Colicin V biosynthesis protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 
 0.744
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
  
 
 0.737
SPRI_3386
Adenine glycosylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
0.699
SPRI_2144
DNA glycosylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the FPG family.
   
  
 0.676
SPRI_4886
DNA glycosylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the FPG family.
   
  
 0.676
SPRI_1382
Exodeoxyribonuclease III; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.675
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
   
  
 0.658
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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