Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRI_3877Serine protease; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (518 aa)    
Predicted Functional Partners:
arc
ATPase AAA; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 0.737
SPRI_1192
Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 0.581
SPRI_3099
Histidine kinase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
  
 0.552
c106_07c
Acyl carrier protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.547
SPRI_7104
Acyl carrier protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.547
rplK
50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
  
 
   0.533
miaA
tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
 
   
 0.518
rpsF
30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
  
 
 0.508
hflX
ATP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
 
  
 0.500
clpP
ATP-dependent Clp protease ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
  
 0.491
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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