close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_4209Exopolyphosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (569 aa)    
Predicted Functional Partners:
SPRI_4210
acetyl-CoA carboxylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.956
SPRI_4212
acyl-CoA dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.948
SPRI_4208
Wyosine base formation domain-containing protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.947
SPRI_4215
TetR-family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.936
SPRI_4211
acetyl-CoA carboxylase subunit alpha; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.871
SPRI_4214
enoyl-CoA hydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.853
hmgA
Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
 
 
 0.841
SPRI_4213
AMP-dependent synthetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
 0.820
SPRI_2823
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.559
SPRI_4205
Transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.555
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.