Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRI_4317FO synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (847 aa)    
Predicted Functional Partners:
fbiA
2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
  
 0.980
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.866
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.830
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.828
SPRI_0388
Protein phosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
   0.794
SPRI_0629
Signal transduction histidine kinase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
   0.794
SPRI_1515
Magnesium or manganese-dependent protein phosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
   0.794
SPRI_1751
Diguanylate cyclase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
   0.794
SPRI_6622
Protein phosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
   0.794
SPRI_6640
Magnesium or manganese-dependent protein phosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
   0.794
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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