STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ahcY-2S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (485 aa)    
Predicted Functional Partners:
SPRI_0180
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.956
SPRI_5899
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.956
SPRI_4467
Cystathionine beta-synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.929
SPRI_2931
Cystathionine gamma-synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.923
SPRI_4676
DNA methylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
    
 0.906
SPRI_4677
5-methylcytosine methyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.906
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
  
 
0.900
SPRI_1856
Homocysteine methyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
  0.900
SPRI_3595
Bifunctional beta-cystathionase/maltose regulon regulatory protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
  0.900
SPRI_3832
Cystathionine gamma-lyase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.847
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.