Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SPRI_46234-hydroxyphenylpyruvate dioxygenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (381 aa)    
Predicted Functional Partners:
hmgA
Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
 
 0.997
SPRI_3259
Fumarylacetoacetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
  
 0.934
pat
Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
    
 0.915
SPRI_3209
Aspartate aminotransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 
 0.913
hisC
Aspartate aminotransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
    
 0.911
SPRI_5666
Aminotransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
    
 0.910
SPRI_1365
Amidase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the amidase family.
  
 
  0.817
SPRI_1450
Amidase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the amidase family.
  
 
  0.817
SPRI_4622
AsnC family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
     0.795
SPRI_4621
ArsR family transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.707
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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