Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nadDNicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (211 aa)    
Predicted Functional Partners:
rsfS
Iojap superfamily protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.978
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.968
SPRI_4633
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 
 0.963
SPRI_2149
Damage-inducible protein CinA; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the CinA family.
 
 
 0.960
SPRI_5759
Transcriptional regulator; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
 0.957
SPRI_3401
Nicotinate-nucleotide pyrophosphorylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family.
    
 0.955
nadK
Inorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
 
 0.952
SPRI_1346
NAD-dependent deacetylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
   
 0.933
SPRI_4944
Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
     
 0.918
SPRI_4006
5'-nucleotidase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.
     
 0.914
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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