Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPRI_4962AMP-dependent synthetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (629 aa)    
Predicted Functional Partners:
SPRI_0389
acyl-CoA carboxylase complex A subunit; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.814
SPRI_2955
acetyl-CoA carboxylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.814
SPRI_0186
PII peptide synthetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
 0.723
SPRI_7167
PII peptide synthetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
 0.723
SPRI_4963
Protein phosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
       0.722
SPRI_4964
Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
       0.715
SPRI_0203
Putative acyl-CoA ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
0.709
lepA
Elongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
       0.709
SPRI_0801
AMP-dependent synthetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
0.697
SPRI_6937
acyl-CoA synthetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
0.688
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.