Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (587 aa)    
Predicted Functional Partners:
leuC
Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.996
leuD
Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.992
SPRI_2341
Branched-chain amino acid aminotransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 0.987
ilvD
Dihydroxy-acid dehydratase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
 
 
 0.979
SPRI_2357
Acetolactate synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
 
 
 0.977
SPRI_6019
Class IV aminotransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 0.971
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 
 
 0.951
SPRI_3474
Pyruvate carboxylase subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.949
SPRI_0389
acyl-CoA carboxylase complex A subunit; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.943
SPRI_2955
acetyl-CoA carboxylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology.
  
 
 0.943
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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