node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDL59340.1 | SDM03047.1 | SAMN04488535_0095 | SAMN04488535_1635 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | 0.482 |
SDL59340.1 | SDM14080.1 | SAMN04488535_0095 | SAMN04488535_2077 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | dTMP kinase. | 0.536 |
SDL59340.1 | dut | SAMN04488535_0095 | SAMN04488535_0718 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.521 |
SDL59340.1 | fmt | SAMN04488535_0095 | SAMN04488535_0600 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.919 |
SDL59340.1 | folD | SAMN04488535_0095 | SAMN04488535_2004 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.509 |
SDL59340.1 | glyA | SAMN04488535_0095 | SAMN04488535_0196 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.914 |
SDL59340.1 | purH | SAMN04488535_0095 | SAMN04488535_0111 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.902 |
SDL59340.1 | purN | SAMN04488535_0095 | SAMN04488535_0110 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.905 |
SDL59340.1 | thyA | SAMN04488535_0095 | SAMN04488535_0096 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
SDL59340.1 | thyX | SAMN04488535_0095 | SAMN04488535_0784 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.979 |
SDM03047.1 | SDL59340.1 | SAMN04488535_1635 | SAMN04488535_0095 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.482 |
SDM03047.1 | fmt | SAMN04488535_1635 | SAMN04488535_0600 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.586 |
SDM03047.1 | folD | SAMN04488535_1635 | SAMN04488535_2004 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.925 |
SDM03047.1 | glyA | SAMN04488535_1635 | SAMN04488535_0196 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |
SDM03047.1 | purH | SAMN04488535_1635 | SAMN04488535_0111 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.540 |
SDM03047.1 | purN | SAMN04488535_1635 | SAMN04488535_0110 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.533 |
SDM03047.1 | thyA | SAMN04488535_1635 | SAMN04488535_0096 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.906 |
SDM03047.1 | thyX | SAMN04488535_1635 | SAMN04488535_0784 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.911 |
SDM14080.1 | SDL59340.1 | SAMN04488535_2077 | SAMN04488535_0095 | dTMP kinase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.536 |
SDM14080.1 | dut | SAMN04488535_2077 | SAMN04488535_0718 | dTMP kinase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.923 |