node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDO46084.1 | guA | BM1374165_00055 | BM1374165_01662 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamine amidotransferase. | 0.904 |
CDO46084.1 | guaA | BM1374165_00055 | BM1374165_00191 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.961 |
CDO46084.1 | guaB | BM1374165_00055 | BM1374165_00188 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.938 |
CDO47636.1 | CDO47637.1 | BM1374165_01663 | BM1374165_01664 | Hypothetical DNA-binding protein. | Hypothetical membrane protein. | 0.872 |
CDO47636.1 | guA | BM1374165_01663 | BM1374165_01662 | Hypothetical DNA-binding protein. | Glutamine amidotransferase. | 0.647 |
CDO47637.1 | CDO47636.1 | BM1374165_01664 | BM1374165_01663 | Hypothetical membrane protein. | Hypothetical DNA-binding protein. | 0.872 |
CDO47637.1 | guA | BM1374165_01664 | BM1374165_01662 | Hypothetical membrane protein. | Glutamine amidotransferase. | 0.579 |
argS | gmk | BM1374165_01044 | BM1374165_00520 | arginyl-tRNA synthetase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.486 |
argS | guA | BM1374165_01044 | BM1374165_01662 | arginyl-tRNA synthetase. | Glutamine amidotransferase. | 0.593 |
argS | guaA | BM1374165_01044 | BM1374165_00191 | arginyl-tRNA synthetase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.959 |
argS | rplK | BM1374165_01044 | BM1374165_00593 | arginyl-tRNA synthetase. | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.559 |
gmk | argS | BM1374165_00520 | BM1374165_01044 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | arginyl-tRNA synthetase. | 0.486 |
gmk | guA | BM1374165_00520 | BM1374165_01662 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Glutamine amidotransferase. | 0.913 |
gmk | guaA | BM1374165_00520 | BM1374165_00191 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.964 |
gmk | guaB | BM1374165_00520 | BM1374165_00188 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.507 |
guA | CDO46084.1 | BM1374165_01662 | BM1374165_00055 | Glutamine amidotransferase. | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.904 |
guA | CDO47636.1 | BM1374165_01662 | BM1374165_01663 | Glutamine amidotransferase. | Hypothetical DNA-binding protein. | 0.647 |
guA | CDO47637.1 | BM1374165_01662 | BM1374165_01664 | Glutamine amidotransferase. | Hypothetical membrane protein. | 0.579 |
guA | argS | BM1374165_01662 | BM1374165_01044 | Glutamine amidotransferase. | arginyl-tRNA synthetase. | 0.593 |
guA | gmk | BM1374165_01662 | BM1374165_00520 | Glutamine amidotransferase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.913 |