STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rcas_0136PFAM: transcriptional regulator TrmB; KEGG: rrs:RoseRS_0464 transcriptional regulator, TrmB. (261 aa)    
Predicted Functional Partners:
Rcas_0474
PFAM: restriction endonuclease; SH3 type 3 domain protein; KEGG: rrs:RoseRS_4245 restriction endonuclease.
   
    0.845
Rcas_0135
Heavy metal translocating P-type ATPase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein; KEGG: rrs:RoseRS_0463 heavy metal translocating P-type ATPase.
      0.832
Rcas_0618
KEGG: pth:PTH_0862 hypothetical protein.
   
    0.775
Rcas_1002
PFAM: NERD domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: tte:TTE0673 hypothetical protein.
   
    0.775
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
    0.775
Rcas_4414
KEGG: rrs:RoseRS_3443 metallophosphoesterase.
  
     0.638
Rcas_2584
KEGG: rrs:RoseRS_2803 chromosome segregation ATPase-like protein.
  
     0.584
Rcas_1463
KEGG: rrs:RoseRS_4140 Fe-S-cluster-containing hydrogenase components 1-like protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
   
    0.577
Rcas_2172
Cyclic nucleotide-binding protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Polysulphide reductase NrfD; KEGG: rrs:RoseRS_1792 4Fe-4S ferredoxin, iron-sulfur binding domain protein.
   
    0.577
Rcas_0137
PFAM: glycosyl transferase family 2; KEGG: rrs:RoseRS_0466 glycosyl transferase, family 2.
       0.554
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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