node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rcas_0122 | Rcas_4175 | Rcas_0122 | Rcas_4175 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | KEGG: rrs:RoseRS_4314 hypothetical protein. | 0.900 |
Rcas_0122 | fhs | Rcas_0122 | Rcas_0522 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.943 |
Rcas_0122 | fmt | Rcas_0122 | Rcas_3225 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.918 |
Rcas_0122 | folD | Rcas_0122 | Rcas_0735 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.964 |
Rcas_0122 | gcvT | Rcas_0122 | Rcas_2285 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.933 |
Rcas_0122 | purH | Rcas_0122 | Rcas_4336 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | KEGG: rrs:RoseRS_0206 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.912 |
Rcas_0122 | purN | Rcas_0122 | Rcas_3176 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.915 |
Rcas_3006 | fhs | Rcas_3006 | Rcas_0522 | PFAM: methylenetetrahydrofolate reductase; KEGG: rrs:RoseRS_2032 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.488 |
Rcas_3006 | folD | Rcas_3006 | Rcas_0735 | PFAM: methylenetetrahydrofolate reductase; KEGG: rrs:RoseRS_2032 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.933 |
Rcas_3006 | gcvT | Rcas_3006 | Rcas_2285 | PFAM: methylenetetrahydrofolate reductase; KEGG: rrs:RoseRS_2032 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.928 |
Rcas_3006 | glyA | Rcas_3006 | Rcas_1155 | PFAM: methylenetetrahydrofolate reductase; KEGG: rrs:RoseRS_2032 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
Rcas_4175 | Rcas_0122 | Rcas_4175 | Rcas_0122 | KEGG: rrs:RoseRS_4314 hypothetical protein. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | 0.900 |
Rcas_4175 | folD | Rcas_4175 | Rcas_0735 | KEGG: rrs:RoseRS_4314 hypothetical protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.900 |
Rcas_4175 | purN | Rcas_4175 | Rcas_3176 | KEGG: rrs:RoseRS_4314 hypothetical protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
fhs | Rcas_0122 | Rcas_0522 | Rcas_0122 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | 0.943 |
fhs | Rcas_3006 | Rcas_0522 | Rcas_3006 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: methylenetetrahydrofolate reductase; KEGG: rrs:RoseRS_2032 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.488 |
fhs | folD | Rcas_0522 | Rcas_0735 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
fhs | gcvT | Rcas_0522 | Rcas_2285 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.940 |
fhs | glyA | Rcas_0522 | Rcas_1155 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
fhs | purH | Rcas_0522 | Rcas_4336 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: rrs:RoseRS_0206 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.989 |