STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menA1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (300 aa)    
Predicted Functional Partners:
Rcas_2224
PFAM: thioesterase superfamily protein; KEGG: rrs:RoseRS_2446 thioesterase superfamily protein.
 
  
 0.942
menG
Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
 
  
 0.930
Rcas_0808
PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: mta:Moth_1443 UbiE/COQ5 methyltransferase.
    
 0.908
Rcas_1178
PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: rrs:RoseRS_0807 methyltransferase type 11.
    
 0.908
Rcas_0981
TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; KEGG: rrs:RoseRS_0431 hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family.
   
 
 0.876
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
 
   
 0.854
menD
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
   
 0.849
Rcas_3751
TIGRFAM: geranylgeranyl reductase; PFAM: monooxygenase FAD-binding; KEGG: rrs:RoseRS_3265 geranylgeranyl reductase.
    
 0.829
Rcas_4216
KEGG: rrs:RoseRS_0026 isochorismate synthase; TIGRFAM: isochorismate synthase; PFAM: Anthranilate synthase component I and chorismate binding protein.
 
   
 0.716
menH
Alpha/beta hydrolase fold; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
 
 
 
 0.587
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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