node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rcas_3261 | htpX | Rcas_3261 | Rcas_3260 | Multi-sensor signal transduction histidine kinase; PFAM: GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: rrs:RoseRS_1983 multi-sensor signal transduction histidine kinase. | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.538 |
Rcas_3280 | grpE | Rcas_3280 | Rcas_4391 | PFAM: peptidase M41; AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: rrs:RoseRS_1848 AAA ATPase, central domain protein; Belongs to the AAA ATPase family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.504 |
Rcas_3280 | htpX | Rcas_3280 | Rcas_3260 | PFAM: peptidase M41; AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: rrs:RoseRS_1848 AAA ATPase, central domain protein; Belongs to the AAA ATPase family. | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.490 |
ftsH | grpE | Rcas_0717 | Rcas_4391 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.504 |
ftsH | htpX | Rcas_0717 | Rcas_3260 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.490 |
grpE | Rcas_3280 | Rcas_4391 | Rcas_3280 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | PFAM: peptidase M41; AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: rrs:RoseRS_1848 AAA ATPase, central domain protein; Belongs to the AAA ATPase family. | 0.504 |
grpE | ftsH | Rcas_4391 | Rcas_0717 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.504 |
grpE | htpX | Rcas_4391 | Rcas_3260 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.550 |
grpE | msrB | Rcas_4391 | Rcas_3054 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; KEGG: rrs:RoseRS_2424 methionine-R-sulfoxide reductase. | 0.551 |
htpX | Rcas_3261 | Rcas_3260 | Rcas_3261 | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | Multi-sensor signal transduction histidine kinase; PFAM: GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: rrs:RoseRS_1983 multi-sensor signal transduction histidine kinase. | 0.538 |
htpX | Rcas_3280 | Rcas_3260 | Rcas_3280 | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | PFAM: peptidase M41; AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: rrs:RoseRS_1848 AAA ATPase, central domain protein; Belongs to the AAA ATPase family. | 0.490 |
htpX | ftsH | Rcas_3260 | Rcas_0717 | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.490 |
htpX | grpE | Rcas_3260 | Rcas_4391 | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.550 |
htpX | msrB | Rcas_3260 | Rcas_3054 | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; KEGG: rrs:RoseRS_2424 methionine-R-sulfoxide reductase. | 0.500 |
msrB | grpE | Rcas_3054 | Rcas_4391 | TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; KEGG: rrs:RoseRS_2424 methionine-R-sulfoxide reductase. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.551 |
msrB | htpX | Rcas_3054 | Rcas_3260 | TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; KEGG: rrs:RoseRS_2424 methionine-R-sulfoxide reductase. | PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1982 peptidase M48, Ste24p; Belongs to the peptidase M48B family. | 0.500 |